Sometimes, run-on sentences work!
I just finished "Agape Agape" by William Gaddis (no immediate relation). Very interesting book... the whole thing is written stream of consciousness... the main character's continual rant of delusion and memory and history, all flowing in and out of each other, almost always transitioning mid-sentence.
The book is written in the first person, an alleged fictional writer (I'm not to sure about that), that is struggling to complete his final work, a book about the creation of the player piano and its roll in the decline of true artistry and ultimately, the decline of western civilization. In his manic attempt to reconcile the content of his book, our writer also attempts to reconcile the content of his life... His failings as a father, disappointments in his career, failing health and the inevitable settlement of his estate after his death.
The structure of the book is challenging. There are no chapters, little punctuation and few sentences, which tend to be very long, very elaborate run-on sentences which traverse time period and subject matter mid stream, but allow the reader to really experience the writers' suffering, angst and urgency. If you're up for a challenge, Agape Agape is a good read.