The search for cancer cure from natural products have been practiced for over a century. For the last 25 years, El-Asmer and co-workers were pursuing the search for potential therapeutic agent or new drug models from snake venoms. This work was presented for partial fulfillment of M.D. in Biochemistry. A cytolytic, non-antigenic, 8 kDa, glycoprotein (Fraction VIb) was isolated from crude Naja nigricollis nigricollis spitting cobra venom. This protein is stable at different pH values and different temperatures up to 100�C, ...
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The search for cancer cure from natural products have been practiced for over a century. For the last 25 years, El-Asmer and co-workers were pursuing the search for potential therapeutic agent or new drug models from snake venoms. This work was presented for partial fulfillment of M.D. in Biochemistry. A cytolytic, non-antigenic, 8 kDa, glycoprotein (Fraction VIb) was isolated from crude Naja nigricollis nigricollis spitting cobra venom. This protein is stable at different pH values and different temperatures up to 100�C, lethal to mice, with LD50 1.83 mg/kg. Small doses induced cytolytic effect on hepatocellular carcinoma, colon cancer and breast cancer cells while larger doses caused hemolysis of red blood cells. Thus, this protein can be considered a target compound for further researches as it can be a potential bio-therapeutic agent for cancer treatment, or a model for new drug design.
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