Stochastic Dynamics for Systems Biology is one of the first books to provide a systematic study of the many stochastic models used in systems biology. The book shows how the mathematical models are used as technical tools for simulating biological processes and how the models lead to conceptual insights on the functioning of the cellular processing system. Most of the text should be accessible to scientists with basic knowledge in calculus and probability theory. The authors illustrate the relevant Markov chain theory ...
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Stochastic Dynamics for Systems Biology is one of the first books to provide a systematic study of the many stochastic models used in systems biology. The book shows how the mathematical models are used as technical tools for simulating biological processes and how the models lead to conceptual insights on the functioning of the cellular processing system. Most of the text should be accessible to scientists with basic knowledge in calculus and probability theory. The authors illustrate the relevant Markov chain theory using realistic models from systems biology, including signaling and metabolic pathways, phosphorylation processes, genetic switches, and transcription. A central part of the book presents an original and up-to-date treatment of cooperativity. The book defines classical indexes, such as the Hill coefficient, using notions from statistical mechanics. It explains why binding curves often have S-shapes and why cooperative behaviors can lead to ultrasensitive genetic switches. These notions are then used to model transcription rates. Examples cover the phage lambda genetic switch and eukaryotic gene expression. The book then presents a short course on dynamical systems and describes stochastic aspects of linear noise approximation. This mathematical framework enables the simplification of complex stochastic dynamics using Gaussian processes and nonlinear ODEs. Simple examples illustrate the technique in noise propagation in gene networks and the effects of network structures on multistability and gene expression noise levels. The last chapter provides up-to-date results on stochastic and deterministic mass action kinetics with applications to enzymatic biochemical reactions and metabolic pathways.
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Add this copy of Stochastic Dynamics for Systems Biology to cart. $75.32, new condition, Sold by discount_scientific_books rated 4.0 out of 5 stars, ships from Sterling Heights, MI, UNITED STATES, published 2014 by CRC Press.
Add this copy of Stochastic Dynamics for Systems Biology to cart. $92.88, very good condition, Sold by ThriftBooks-Dallas rated 5.0 out of 5 stars, ships from Dallas, TX, UNITED STATES, published 2014 by CRC Press.
Add this copy of Stochastic Dynamics for Systems Biology (Chapman & Hall to cart. $140.17, good condition, Sold by Bonita rated 4.0 out of 5 stars, ships from Newport Coast, CA, UNITED STATES, published 2014 by Chapman and Hall/CRC.
Add this copy of Stochastic Dynamics for Systems Biology (Chapman & Hall to cart. $187.60, new condition, Sold by Bonita rated 4.0 out of 5 stars, ships from Newport Coast, CA, UNITED STATES, published 2014 by Chapman and Hall/CRC.
