When rediscovered at the turn of the century, Mendel's laws were found to be applicable to humans, but from the beginning they were fraught with problems. Sex-linked traits and linked genes defied Mendel's rules. Later, other exceptions were found, including sporadic cases, non-penetrance, variable expressivity, and preferential parental transmission. In this book, Harry Ostrer observes that some of these problems can be explained by incomplete ascertainment, typing errors and modifying genes. He then goes on to ...
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When rediscovered at the turn of the century, Mendel's laws were found to be applicable to humans, but from the beginning they were fraught with problems. Sex-linked traits and linked genes defied Mendel's rules. Later, other exceptions were found, including sporadic cases, non-penetrance, variable expressivity, and preferential parental transmission. In this book, Harry Ostrer observes that some of these problems can be explained by incomplete ascertainment, typing errors and modifying genes. He then goes on to systematically explore the evidence for a number of newer genetic processes that were not foreseen by Mendel and his intellectual heirs, examining the molecular basis for these processes and their effects on transmission and phenotype. He shows that these non-Mendelian processes--gonadal and somatic mosaicism, sex-linked inheritance, mitochondrial transmission, genomic imprinting, accelerated rates of mutation, and viral infection--resolve many of the exceptions to Mendelian inheritance. He also provides a complete review of Mendelian genetics, as well as an overview of the structure and functions of genes, chromosomes, and their products. Thus the book presents a holistic view of human genetics. In the last chapter, Ostrer grapples with the possibilities for identifying new genetic processes, and with genetic determinism--the view that a person's phenotype is fully subject to his or her genetic constitution. He contends that despite the large number of genetic combinations, phenotypes cannot be predicted precisely, even with sufficient computing power. Genetic processes are frequently modified by environmental exposure or they may be random or stochastic in their occurrence. Hence, there are innate limits to genetic determinism. Although prediction of phenotype based on genotype will improve in the future as all of the human genes are identified, such predictions will always remain imprecise.
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Add this copy of Non-Mendelian Genetics in Humans to cart. $24.41, very good condition, Sold by Lawrence Jones rated 4.0 out of 5 stars, ships from Nobby Beach, QLD, AUSTRALIA, published 1998 by Oxford University Press.
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Very Good in Very Good jacket. 8vo. x, 202pp, text-figures, index. Cloth boards in jacket. The author shows that non-Mendelian processes resolve many of the exceptions to Mendelian inheritance. He provides a complete review of Mendelian genetics, as well as an overview of the structure and functions of genes, chromosomes, and their products. The last chapter covers the possibilities for identifying new genetic processes and with genetic determinism.
Add this copy of Non-Mendelian Genetics in Humans (Oxford Monographs on to cart. $33.86, good condition, Sold by Bonita rated 4.0 out of 5 stars, ships from Newport Coast, CA, UNITED STATES, published 1998 by Oxford University Press.
Add this copy of Non-Mendelian Genetics in Humans to cart. $34.71, like new condition, Sold by GreatBookPrices rated 4.0 out of 5 stars, ships from Columbia, MD, UNITED STATES, published 1998 by Oxford University Press.
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Fine. Sewn binding. Cloth over boards. 216 p. Oxford Monographs on Medical Genetics, 35. In Stock. 100% Money Back Guarantee. Brand New, Perfect Condition, allow 4-14 business days for standard shipping. To Alaska, Hawaii, U.S. protectorate, P.O. box, and APO/FPO addresses allow 4-28 business days for Standard shipping. No expedited shipping. All orders placed with expedited shipping will be cancelled. Over 3, 000, 000 happy customers.
Add this copy of Non-Mendelian Genetics in Humans to cart. $63.67, new condition, Sold by GreatBookPrices rated 4.0 out of 5 stars, ships from Columbia, MD, UNITED STATES, published 1998 by Oxford University Press.
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New. Sewn binding. Cloth over boards. 216 p. Oxford Monographs on Medical Genetics, 35. In Stock. 100% Money Back Guarantee. Brand New, Perfect Condition, allow 4-14 business days for standard shipping. To Alaska, Hawaii, U.S. protectorate, P.O. box, and APO/FPO addresses allow 4-28 business days for Standard shipping. No expedited shipping. All orders placed with expedited shipping will be cancelled. Over 3, 000, 000 happy customers.
Add this copy of Non-Mendelian Genetics in Humans to cart. $63.68, new condition, Sold by Ingram Customer Returns Center rated 5.0 out of 5 stars, ships from NV, USA, published 1998 by Oxford University Press, USA.
