This monograph serves as a practical, `how-to' guide for the investigator interested in the functional methods used to characterize the murine cardiovascular phenotype. It is assumed that neither the cardiovascular physiologist nor the molecular biologist has a significant familiarity with each other's field; in this sense the content is truly introductory, and therefore valuable for both the scientist/physician and the trainee. A second objective is to help decipher the literature critically and foster an understanding of ...
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This monograph serves as a practical, `how-to' guide for the investigator interested in the functional methods used to characterize the murine cardiovascular phenotype. It is assumed that neither the cardiovascular physiologist nor the molecular biologist has a significant familiarity with each other's field; in this sense the content is truly introductory, and therefore valuable for both the scientist/physician and the trainee. A second objective is to help decipher the literature critically and foster an understanding of the advantages and limitations of each method. Molecular biology, and, more specifically, transgenesis and gene targeting, have progressed at a rapid pace; this work aims to provide a framework for the large amount of information in this proliferating, and often bewildering field. The multidisciplinary nature of the book will facilitate the newly-formed marriage between physiologists and molecular biologists and will stimulate and direct young investigators towards the field. This monograph is organized (somewhat arbitrarily) into three sections. The first deals with transgenic and gene targeting approaches to cardiovascular physiology and pathology. The second and largest section discusses various techniques used to assess the cardiovascular phenotype, including isolated myocyte mechanics and calcium transients, the Langendorff and working isolated heart preparations, NMR spectroscopy, echocardiography, invasive hemodynamics, electrophysiology and telemetric monitoring. The final section examines methods and techniques used to study cardiovascular development, exercise and oxygen consumption in vivo, and the role of genetic manipulations in the study of the vascular system.
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Add this copy of Cardiovascular Physiology in the Genetically Engineered to cart. $19.95, very good condition, Sold by Mike's Library rated 1.0 out of 5 stars, ships from Plymouth, PA, UNITED STATES, published 2001 by Kluwer Academic Publishers.
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Near Fine with no dust jacket. 079237536X. Slightest wear. Crisp NEW hardcover in shrinkwrap.; The enormous advances in molecular biology and genetics coupled with the progress in instrumentation and surgical techniques have produced a voluminous and often bewildering quantity of data. The primary objective of a second edition of Cardiovascular Physiology in the Genetically Engineered Mouse is to interpret critically the literature and to provide a framework for the enormous amount of information in this burgeoning field. As in the first edition, the monograph serves as a practical guide for the investigator interested in the functional methods used to characterize the murine cardiovascular phenotype. The monograph is organized into three parts. The first deals with principles of transgenesis and homologous recombination. The second part, which again is the largest, discusses the various techniques used to assess the cardiovascular mechanical, metabolic, and electrophysiologic phenotype. This section is organized in a hierarchical manner-i.e. from isolated myocyte to isolated heart to the intact, anesthetized and conscious mouse. The third part examines techniques used to evaluate murine smooth muscle function, genetic mouse models of hypertrophy and heart failure, and the methods to assess the cardiovascular phenotype in the developing mouse embryo. In addition, newer methods that `push the envelope', such as magnetic resonance imaging (MRI), positron emission tomography (PET), ultrasound biomicroscopy (UBM), and computed tomography (microCT) are discussed. Expanded and updated, each chapter is richly enhanced with original tables and figures, and in many cases, extensively rewritten when compared with the first edition. An essential and enduring goal of this second edition is to continue to facilitate interactions between the basic science disciplines and help bridge the gap between molecular biology and physiology.; Developments in Cardiovascular Medicine; Vol. 238; xii, 403 pages.
Add this copy of Cardiovascular Physiology in the Genetically Engineered to cart. $50.49, good condition, Sold by Bonita rated 4.0 out of 5 stars, ships from Newport Coast, CA, UNITED STATES, published 2001 by Kluwer Academic Publishers.
Add this copy of Cardiovascular Physiology in the Genetically Engineered to cart. $59.00, very good condition, Sold by Xerxes Books rated 5.0 out of 5 stars, ships from Glen Head, NY, UNITED STATES, published 1998 by Springer.
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Seller's Description:
Norwell, Mass. 1998 Kluwer. ISBN 0-7923-8356-7. Hardcover. Octavo, 286pp. "Final Sale" stamp on front free blank. Near Fine. no owner marks. Slight cover rubbing., no dj (as issued)
Add this copy of Cardiovascular Physiology in the Genetically Engineered to cart. $85.79, new condition, Sold by Basi6 International rated 5.0 out of 5 stars, ships from Irving, TX, UNITED STATES, published 1998 by Springer.
Add this copy of Cardiovascular Physiology in the Genetically Engineered to cart. $122.66, new condition, Sold by Media Smart rated 3.0 out of 5 stars, ships from Hawthorne, CA, UNITED STATES, published 1998 by Springer.
