Shaun D. McCullough

Dr. McCullough's lab focuses around the role of the epigenome as both a molecular mechanism mediating the effects of toxic exposures and as a biomarker for predicting susceptible populations and identifying factors that can be used to mitigate adverse exposure outcomes. The lab employs a translational research approach to toxicology that uses both advanced in vitro primary cell models and in vivo clinical controlled human exposure studies. Dr. McCullough completed his postdoctoral training at...See more

Dr. McCullough's lab focuses around the role of the epigenome as both a molecular mechanism mediating the effects of toxic exposures and as a biomarker for predicting susceptible populations and identifying factors that can be used to mitigate adverse exposure outcomes. The lab employs a translational research approach to toxicology that uses both advanced in vitro primary cell models and in vivo clinical controlled human exposure studies. Dr. McCullough completed his postdoctoral training at the US EPA where he identified novel pathways of single and multi-toxicant mediated stress, for which he received the Molecular and Systems Biology Specialty Section Postdoctoral Fellow Award, the US EPA Superior Achievement Award, and the Gabriel L. Plaa Education Award. Dr. McCullough's research is focused on investigating the role of the epigenome as a mediator of inter-individual variability in toxicant-induced health effects and susceptibility using in vitro and human exposure models. Dr. McCullough is the Chairman of the US EPA's National Health and Environmental Effects Research Laboratory Epigenetics Workgroup, a founding member of the University of North Carolina's Program in Chromatin and Epigenetics, and is on the Board of Directors for the American Society for Cellular and Computational Toxicology. See less