Transcription factors are key players in the execution of the genomic program of any given cell. Their control over complex patterns of gene expression governs essentially every step in the development, growth and differentiation of an organ- ism as well as its physiological responses to external stimuli. An Introduction to Transcription Factors, the first part of this volume, de- scribes the varied and combinatorial mechanisms involved in the two basic modes of transcriptional control, activation (the chapter by Herrera et ...
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Transcription factors are key players in the execution of the genomic program of any given cell. Their control over complex patterns of gene expression governs essentially every step in the development, growth and differentiation of an organ- ism as well as its physiological responses to external stimuli. An Introduction to Transcription Factors, the first part of this volume, de- scribes the varied and combinatorial mechanisms involved in the two basic modes of transcriptional control, activation (the chapter by Herrera et al.) and repression (the chapter by Arnosti). Overlaying both modes is an emerging emphasis on epigenetic regulation that uses intricate patterns of chromatin modi- fication. Although many of these mechanisms have been elucidated by studying prototypical genes or transcription factors, the recently developed tools of ge- nomic biology allow us to unravel the complexity of global transcriptional pro- grams with an ever-increasing speed and accuracy (the chapter by Zacharewski and La Pres). Given the central role that transcription factors playas relays positioned be- tween the genome and the intracellular and extracellular signals to which cells must respond, it is not surprising that these regulatory proteins playa major role in pathological processes. Part 2 of this volume, Transcription Factors in Patho- physiology, introduces a selection of specific transcription factors and their families. Each of these factors has a well-established function in basic cellular mechanisms that, upon dysregulation, can cause or contribute to human disease.
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Add this copy of Transcription Factors (Handbook of Experimental to cart. $59.38, good condition, Sold by Bonita rated 4.0 out of 5 stars, ships from Newport Coast, CA, UNITED STATES, published 2012 by Springer.
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This is an ex-library book and may have the usual library/used-book markings inside. This book has hardback covers. Clean from markings In good all round condition. No dust jacket. Please note the Image in this listing is a stock photo and may not match the covers of the actual item, 1000grams, ISBN: 9783540210955.
Add this copy of Transcription Factors: With Contributions By Numerous to cart. $159.70, new condition, Sold by discount_scientific_books rated 4.0 out of 5 stars, ships from Sterling Heights, MI, UNITED STATES, published 2004 by Springer.
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