This historic book may have numerous typos and missing text. Purchasers can download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1906 edition. Excerpt: ...organic acids, especially of /3-oxy-butyric acid, CHS-CHOH-CH2C0OH, and its oxidation products, aceto-acetic acid, CHS-CO-CHC0OH, and acetone, CH3-CO-CH3. These substances can usually be detected in the urine in diabetes previous to the onset of the coma, and during the coma they considerably increase in ...
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This historic book may have numerous typos and missing text. Purchasers can download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1906 edition. Excerpt: ...organic acids, especially of /3-oxy-butyric acid, CHS-CHOH-CH2C0OH, and its oxidation products, aceto-acetic acid, CHS-CO-CHC0OH, and acetone, CH3-CO-CH3. These substances can usually be detected in the urine in diabetes previous to the onset of the coma, and during the coma they considerably increase in amount. It has, not unfrequently, been noted that during the comatous state the breath smells of acetone, and further, that when this state supervenes, the amount of acetone in the urine becomes less, while that of its precursors, /3-oxy-butryic acid and aceto-acetic acid, becomes greater. These facts would seem to indicate that the coma is due to an excess, either of acetone or of the acids in the organism. The smell of acetone on the breath has been taken to point to an intoxication by this substance as the cause of the condition. Such a view would seem to be substantiated by the fact that when acetone is given to dogs in the dosage of 4 grm. per kg. body weight intoxication symptoms follow, like those produced by ethyl alcohol, and if this dose be doubled, death may result. A closer examination of this result, however, instead of proving the contention, at once disproves it, for if 8 grm. per kg. be the minimal lethal dose, then at least 500 grm. would require to be produced in a man of 70 kg. to cause death, and it is inconceivable how such could be the case, especially since, in most cases, it would all have to be derived from proteid and fat. Let us then consider whether the acids may not be the cause of the intoxication. They increase in amount in the urine at the expense of acetone, just before, and during the coma, and if bicarbonate of soda be given by mouth to the patient, or if faintly alkaline intravenous saline injections be made, ..
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Add this copy of Recent Advances in Physiology and Bio-Chemistry to cart. $19.28, good condition, Sold by Anybook rated 4.0 out of 5 stars, ships from Lincoln, UNITED KINGDOM, published 1906 by Edward Arnold.
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Seller's Description:
This is an ex-library book and may have the usual library/used-book markings inside. This book has hardback covers. In good all round condition. No dust jacket. Please note the Image in this listing is a stock photo and may not match the covers of the actual item, 1300grams, ISBN:
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