Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability - one of the most significant hurdles in drug discovery and development. - Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability - Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development - Explains how preclinical animal models - used in ...
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Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability - one of the most significant hurdles in drug discovery and development. - Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability - Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development - Explains how preclinical animal models - used in preclinical testing - and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development - Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS) - Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development
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