High-dose therapy with allogeneic or autologous stem cell transplantation as well as additional supportive measures have brought important advances in the therapy of malignant disease. Allogeneic and especially autologous peripheral stem cell grafting as opposed to allogeneic bone marrow transplantation is a subject of intense research. This book summarizes findings in this field, both in basic and clinical research, including newly developed methods. In this context, emphasis has been placed on: acute and chronic myeloid ...
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High-dose therapy with allogeneic or autologous stem cell transplantation as well as additional supportive measures have brought important advances in the therapy of malignant disease. Allogeneic and especially autologous peripheral stem cell grafting as opposed to allogeneic bone marrow transplantation is a subject of intense research. This book summarizes findings in this field, both in basic and clinical research, including newly developed methods. In this context, emphasis has been placed on: acute and chronic myeloid and lymphocytic leukaemia; multiple myeloma; myelodysplastic syndromes; aplastic anaemia and autoimmune disease; and certain solid tumours (carcinomas of the breast, the ovary, the bronchia, the germ cell, and soft tissue sarcoma). Novel approaches such as metakine transplantation and gene therapy are outlined from a theoretical as well as a practical point of view. The crucial question of early and late complications in allogeneic transplantation for solid tumors is dealt with in expert contributions. A special section is dedicated to cord blood transplantation.
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