Recent findings of acrylamide in foods have sparked new interest in assessing human health hazards due to long-term exposure to this vinyl compound. Acrylamide is tumorigenic at high doses in rodents but cancer risk projections in the human population remain uncertain as the molecular pathogenesis of acrylamide at the low dietary uptake is not understood. The present work addresses the question whether transcriptional responses amplify the known genotoxicity of acrylamide. Using DNA microarrays and PCR validations, we ...
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Recent findings of acrylamide in foods have sparked new interest in assessing human health hazards due to long-term exposure to this vinyl compound. Acrylamide is tumorigenic at high doses in rodents but cancer risk projections in the human population remain uncertain as the molecular pathogenesis of acrylamide at the low dietary uptake is not understood. The present work addresses the question whether transcriptional responses amplify the known genotoxicity of acrylamide. Using DNA microarrays and PCR validations, we assessed genome-wide messenger profiles induced in human cells by acrylamide and glycidamide, its more reactive metabolite. The expression changes are characterized by the up-regulation of cytoprotective factors including the GSH system and multiple antioxidants. Low-dose experiments indicate that EPHX1 represents the most sensitive biomarker for glycidamide exposure. At higher concentrations, glycidamide induces markers of tumor progression, while growth suppressors and cell adhesion molecules are down-regulated. These findings indicate that tumor-promoting transcriptional signatures may be expected only at higher doses that exceed the ordinary dietary exposure.
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Add this copy of Glycidamide-Induced Expression Signature to cart. $50.70, new condition, Sold by GreatBookPrices rated 4.0 out of 5 stars, ships from Columbia, MD, UNITED STATES, published 2009 by Sudwestdeutscher Verlag Fur Hochschulschriften AG.
Edition:
2009, Sudwestdeutscher Verlag Fur Hochschulschriften AG
Publisher:
Sudwestdeutscher Verlag Fur Hochschulschriften AG
Published:
2009
Language:
English
Alibris ID:
18145819849
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New. Trade paperback (US). Glued binding. 56 p. In Stock. 100% Money Back Guarantee. Brand New, Perfect Condition, allow 4-14 business days for standard shipping. To Alaska, Hawaii, U.S. protectorate, P.O. box, and APO/FPO addresses allow 4-28 business days for Standard shipping. No expedited shipping. All orders placed with expedited shipping will be cancelled. Over 3, 000, 000 happy customers.
Add this copy of Glycidamide-Induced Expression Signature to cart. $93.66, like new condition, Sold by GreatBookPrices rated 4.0 out of 5 stars, ships from Columbia, MD, UNITED STATES, published 2009 by Sudwestdeutscher Verlag Fur Hochschulschriften AG.
Edition:
2009, Sudwestdeutscher Verlag Fur Hochschulschriften AG
Publisher:
Sudwestdeutscher Verlag Fur Hochschulschriften AG
Published:
2009
Language:
English
Alibris ID:
18152600061
Shipping Options:
Standard Shipping: $4.99
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Seller's Description:
Fine. Trade paperback (US). Glued binding. 56 p. In Stock. 100% Money Back Guarantee. Brand New, Perfect Condition, allow 4-14 business days for standard shipping. To Alaska, Hawaii, U.S. protectorate, P.O. box, and APO/FPO addresses allow 4-28 business days for Standard shipping. No expedited shipping. All orders placed with expedited shipping will be cancelled. Over 3, 000, 000 happy customers.
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Edition:
2009, Sudwestdeutscher Verlag Fur Hochschulschriften AG