Volume 1 List of Contributors xiii Foreword xxiii Preface xxv Part I Fundamentals 1 1 Introduction to Tissue Engineering 3 Rami Mhanna and Anwarul Hasan 1.1 Introduction 3 1.2 Clinical Need for Tissue Engineering and Regenerative Medicine 4 1.3 History of Tissue Engineering and Regenerative Medicine 5 1.4 Fundamentals of Tissue Engineering and Regenerative Medicine 6 1.5 Applications of Tissue Engineering 14 1.6 Challenges in Tissue Engineering 21 1.7 The Future of Tissue Engineering 22 1.8 Conclusions 23 ...
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Volume 1 List of Contributors xiii Foreword xxiii Preface xxv Part I Fundamentals 1 1 Introduction to Tissue Engineering 3 Rami Mhanna and Anwarul Hasan 1.1 Introduction 3 1.2 Clinical Need for Tissue Engineering and Regenerative Medicine 4 1.3 History of Tissue Engineering and Regenerative Medicine 5 1.4 Fundamentals of Tissue Engineering and Regenerative Medicine 6 1.5 Applications of Tissue Engineering 14 1.6 Challenges in Tissue Engineering 21 1.7 The Future of Tissue Engineering 22 1.8 Conclusions 23 References 24 2 Biomaterials in Tissue Engineering 35 Samad Ahadian, Rahaf Rahal, Javier Ram???n-Azc???n, Raquel Obreg???n, and Anwarul Hasan 2.1 Introduction 35 2.2 Biomaterial-Tissue Interactions 37 2.3 Properties of Biomaterials 40 2.4 Scaffold Requirements for Specific Tissues 44 2.5 Classification of Biomaterials 45 2.6 Fabrication Methods of Biomaterials 61 2.7 Testing of Biomaterials 64 2.8 Challenges for Biomaterials in Tissue Engineering 65 2.9 Conclusions and Future Directions 67 Acknowledgment 69 Abbreviations 69 References 70 3 Harnessing the Potential of Stem Cells from Different Sources for Tissue Engineering 85 Divya Murali, Kunal G. Kshirsagar, Anwarul Hasan, and Arghya Paul 3.1 Introduction 85 3.2 Stem Cells in Tissue Engineering 86 3.3 Unique Properties 86 3.4 Types of Stem Cells 87 3.5 Application of Stem Cells in Tissue Engineering 92 3.6 Challenges and Future Directions 101 3.7 Conclusion 102 Acknowledgments 102 References 102 4 Induced Pluripotent Stem Cells in Scaffold-Based Tissue Engineering 111 Deepti Rana, Minal Thacker, Maria Leena, and Murugan Ramalingam 4.1 Introduction 111 4.2 Basics of Induced Pluripotent Stem Cells 112 4.3 Concept of Scaffold-Based Tissue Engineering 116 4.4 Cell-Scaffold Interactions 118 4.5 Application of Induced Pluripotent Stem Cells 121 4.6 Concluding Remarks 134 Acknowledgments 134 References 134 5 Biosensors for Optimal Tissue Engineering: Recent Developments and Shaping the Future 143 Jihane Abouzeid, Ghinwa Darwish, and Pierre Karam 5.1 Introduction 143 5.2 Fundamentals of Biosensors 143 5.3 Biosensing Techniques 145 5.4 Real-Time Sensing in Tissue Engineering and Cell Growth 147 5.5 In Vivo Implementations and the Challenges Faced 155 5.6 Conclusion and Future Directions 158 References 159 6 Bioreactors in Tissue Engineering 169 Raquel Obreg???n, Javier Ram???n-Azc???n, and Samad Ahadian 6.1 Introduction 169 6.2 Bioreactors 170 6.3 Applications of Bioreactors in Tissue Engineering 175 6.4 Summary and Future Perspectives 191 Acknowledgment 191 Abbreviations 191 References 192 Part II Applications 215 7 Tissue-Engineered Human Skin Equivalents and Their Applications in Wound Healing 217 Lara Yildirimer, Divia Hobson, Zhi Yuan (William) Lin,Wenguo Cui, and Xin Zhao 7.1 Introduction 217 7.2 Development of Tissue-Engineered Human Skin Equivalents 220 7.3 Application of TESs inWound Healing 226 7.4 Conclusions and Future Directions 233 Acknowledgments 234 References 234 8 Articular Cartilage Tissue Engineering 243 Jiayin Fu, Pengfei He, and Dong-An Wang 8.1 Introduction 243 8.2 Articular Cartilage Lesions and Repair 245 8.3 Basics of Articular Cartilage Tissue Engineering 248 8.4 Strategies in Current Cartilage Tissue Engineering 265 8.5 Conclusions and Future Directions 273 List of Abbreviations 275 References 276 9 Liver Tissue Engineering 297 Jessica L. Sparks 9.1 Introduction 297 9.2 Liver Biology 299 9.3 Liver Biomechanics 304 9.4 Liver Mechanobiology 308 9.5 Biophysical Stimuli in Liver Tissue Engineering Scaffolds 313 9.6 Conclusion and Future Directions 314 References 314 10 Development of Tissue-Engineered Blood Vessels 325 Haiyan Li 10.1 Introduction 325 10.2 Biology of Blood Vessels 326 10.3 Tissue Engineering of Blood Vessels 329 10.4 Conclusion and Perspective 344 Acknowledgment 345 References 345 Volume 2 Foreword xv Preface xvii
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