More than 15 years have passed since publication of the last monograph on anthracyclineantibiotics,theACSSymposium Series574,edited byW.Priebe. However, anthracycline antibiotics continue to be one of the most applied antitumor agents, mostly in combination therapy. In addition, a number of exciting new developments such as prodrug development or new synthetic, semi-synthetic, or biosynthetic derivatives have emerged in spite of a certain decrease in synthetic activity. With this background in mind, I accepted the ...
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More than 15 years have passed since publication of the last monograph on anthracyclineantibiotics,theACSSymposium Series574,edited byW.Priebe. However, anthracycline antibiotics continue to be one of the most applied antitumor agents, mostly in combination therapy. In addition, a number of exciting new developments such as prodrug development or new synthetic, semi-synthetic, or biosynthetic derivatives have emerged in spite of a certain decrease in synthetic activity. With this background in mind, I accepted the invitation of Prof. J. Thiem to edit an updated collection of reviews on - thracyclineantibiotics. Infact,thistaskturnedouttobeanexciting endeavor andinsteadoftheinitiallyplannedsinglevolume,thenumerouscontributions frommany experts in this exciting ?eld had to be collected into two volumes. Thelast decadehasprovidedamuchgreater amountofnewinformationthen initially anticipated and these volumes represent a condensed review of this data derived fromjournals representing quite different ?elds. The ?rst volume is dedicated to biological occurrence and biosynthesis as well as the synthesis and chemistry of anthracyclines. Since the pioneering review of H. Brockmann on naturally occurring anthracyclines in 1963, no systematic overview has appeared and this volume will provide a review of the latest information. This topic is closely related to biosynthesis and the intriguing progress in biotechnology to produce biosynthetic anthracycline variants is presented. The part of the volume covering synthesis comprises an updated overview on asymmetric synthesis, combinatorial synthesis using the Diels-Alder reaction, synthesis of ?uorinated anthracyclines, the sugar moieties, non-natural glycosyl anthraquinones as DNA binding and pho- cleaving agents, and ?nally of anthracyclines and fredericamycin A via strong base-induced cycloadditionreaction.
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Add this copy of Anthracycline Chemistry and Biology I: Biological to cart. $309.99, new condition, Sold by Ingram Customer Returns Center rated 5.0 out of 5 stars, ships from NV, USA, published 2010 by Springer-Verlag Berlin and Heidelberg GmbH & Co. K.
Edition:
2010, Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Publisher:
Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Published:
2010
Language:
English
Alibris ID:
11794618719
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New. Print on demand Contains: Illustrations, black & white. Topics in Current Chemistry . XIV, 324 p. 135 illus. Intended for professional and scholarly audience.
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Add this copy of Anthracycline Chemistry and Biology I to cart. $178.28, new condition, Sold by discount_scientific_books rated 4.0 out of 5 stars, ships from Sterling Heights, MI, UNITED STATES, published 2008 by Springer.
Add this copy of Anthracycline Chemistry and Biology I to cart. $185.82, new condition, Sold by discount_scientific_books rated 4.0 out of 5 stars, ships from Sterling Heights, MI, UNITED STATES, published 2008 by Springer.
