Von drei weltbekannten Pharmazeuten herausgegeben, widmet sich dieser Band erstmals der "gr???nen" Chemie im Umfeld der pharmazeutischen Industrie. Dabei geht es um einfache kleine Molek???le genauso wie um komplexe Proteine, um pharmazeutische Grundlagenforschung und um das Schicksal von Wirkstoffen in der Umwelt. Die handliche Monographie enth???lt zahlreiche bisher nicht publizierte Informationen, dazu ???berzeugende Fallstudien aus der Industrie (Taxol, Pregabalin, Crestor etc.), die zeigen, inwieweit ein multidisziplin ...
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Von drei weltbekannten Pharmazeuten herausgegeben, widmet sich dieser Band erstmals der "gr???nen" Chemie im Umfeld der pharmazeutischen Industrie. Dabei geht es um einfache kleine Molek???le genauso wie um komplexe Proteine, um pharmazeutische Grundlagenforschung und um das Schicksal von Wirkstoffen in der Umwelt. Die handliche Monographie enth???lt zahlreiche bisher nicht publizierte Informationen, dazu ???berzeugende Fallstudien aus der Industrie (Taxol, Pregabalin, Crestor etc.), die zeigen, inwieweit ein multidisziplin???rer Ansatz Effizienz und Umweltfreundlichkeit der Prozesse bef???rdern kann. Ein abschlie???endes Kapitel befasst sich mit eindrucksvollen Technologien und technischen Hilfsmitteln.
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Very good. No dust jacket. Ex-library. Glued binding. Paper over boards. 370 p. Contains: Illustrations, color, Tables, black & white, Figures. Green Chemistry (Wiley). Audience: General/trade. Green chemistry in the pharmaceutical industry Author: Peter J Dunn Publisher: Weinheim: Wiley-VCH, 2011. Series: Green chemistry Summary: * Packed with brand-new information, including severalindustrial case studies * Green Chemistry in the Pharmaceutical Industry is amultidisciplinary endeavour, requiring contributions from chemists, chemical engineers and molecular biologists. * The book contains several prominent case studies, e.g. Subjects Environmental chemistry--Industrial applications Environmental chemistry--Industrial applications--Case studies Pharmaceutical industry--Environmental aspects ISBN: 9783527324187 3527324186 OCLC Number: 753071560 Description: XVIII, 370 Seiten: lll., Diagramme; 240 x 170 mm. Contents: INTRODUCTION TO GREEN CHEMISTRY, ORGANIC SYNTHESIS ANDPHARMACEUTICALS The Development of Organic Synthesis The Environmental Factor The Role of Catalysis Green Chemistry: Benign by Design Ibuprofen Manufacture The Question of Solvents: Alternative Reaction Media Biocatalysis: Green Chemistry Meets White Biotechnology Conclusions and Prospects GREEN CHEMISTRY METRICS Introduction Measuring Resource Usage Life Cycle Assessment (LCA) Measuring Chemistry and Process Efficiency Measuring Process Parameters and Emissions Real Time Analysis Operational Efficiency Measuring Energy Measuring the Toxicity of All the Substrates Measuring Degradation Potential Measuring the Inherent Safety of Lack of Inherent Safety Conclusions SOLVENT USE AND WASTE ISSUES Introduction to Solvent Use and Waste Issues Solvent and Process Greenness Scoring and Selection Tools Waste Minimization and Solvent Recovery ENVIRONMENTAL AND REGULATORY ASPECTS Historical Perspective Pharmaceuticals in the Environment Environmental Regulations A Look to the Future SYNTHESIS OF SITAGLIPTIN, THE ACTIVE INGREDIENT IN JANUVIA ANDJANUMET Introduction First-Generation Route Sitagliptin through Diastereoselective Hydrogenation of an Enamine. The PGA Enamine-Ester Route The Triazole Fragment Direct Preparation of Beta-Keto Amides Second-Generation Chiral Auxiliary Route. The PGA Enamine-AmideRoute Prufication and Isolation of Sitagliptin (PharmaceuticalForm) The Final Manufacturing Route THE DEVELOPMENT OF SHORT, EFFICIENT, ECONOMIC, AND SUSTAINABLECHEMOENZYMATIC PROCESSES FOR STATIN SIDE CHAINS Introduction: Biocatalysis The Relevance of Statins Biocatalytic Routes to Statin Side Chains 2-Deoxy-D-Ribose 5-Phosphate Aldolase (DERA)-Based Routes to StatinIntermediates Conclusions THE TAXOL STORY-DEVELOPMENT OF A GREEN SYNTHESIS VIA PLANT CELLFERMENTATION Introduction Discovery and Early Development From Extraction of Taxol from Pacific Yew Tree Bark toSemi-Synthetic Taxol Taxol from Plant Cell Fermentation Comparison of Semi-Synthetic versus PCF Taxol Processes: TheEnvironmental Impact Comparison of Semi-Synthetic versus PCF Taxol: Green ChemistryPrinciples Final Words THE DEVELOPMENT OF A GREEN, ENERGY EFFICIENT, CHEMOENZYMATICMANUFACTURING PROCESS OF PREGABALIN Introduction Process Routes to Pregabalin Biocatalytic Route to Pregabalin Green Chemistry Considerations Conclusions GREEN PROCESSES FOR PEPTIDE MIMETIC DIABETIC DRUGS Introduction Green Chemistry Considerations in Peptide-like APImanufacture Purification Process to Manufacture Amorphous API Preparation of Unnatural Amino Acids Summary THE DEVELOPMENT OF AN ENVIRONMENTALLY SUSTAINABLE PROCESS FORRADAFAXINE Introduction Chemistry Process and the Dynamic Kinetic Resolution (DKR) Multicolumn Chromatography? Development of Route 4 Environmental Assessment Summary CONTINUOUS PROCESSING IN THE PHARMACEUTICAL INDUSTRY Introduction Continuous Production of a Key Intermediate for Atorvastatin Continuous Process to Prepare Celecoxib Continuous Oxidation of Alcohols to Aldehydes Continuous Production of Bromonitromethane Continuous Production and Use of Diazomehtane A Snapshot of Some Further Continuous Processes Used in thePreparation of Pharmaceutical Agents Conclusions PREPARATIVE AND INDUSTRIAL...
Add this copy of Green Chemistry in the Pharmaceutical Industry (Hb 2010 to cart. $123.60, Sold by Books International rated 3.0 out of 5 stars, ships from Toronto, ON, CANADA, published 2010 by Wiley-Vch.
Add this copy of Green Chemistry in the Pharmaceutical Industry (Hb 2010 to cart. $154.68, new condition, Sold by discount_scientific_books rated 5.0 out of 5 stars, ships from Sterling Heights, MI, UNITED STATES, published 2010 by Wiley-Vch.
Add this copy of Green Chemistry in the Pharmaceutical Industry to cart. $159.20, new condition, Sold by Media Smart rated 4.0 out of 5 stars, ships from Hawthorne, CA, UNITED STATES, published 2010 by John Wiley & Sons.
